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Buy MDMA Ecstasy Online

Common names: MDMA, Molly, Mandy, MD, Ecstasy, E, X, XTC, Rolls
Substitutive name: 3,4-Methylenedioxy-N-methylamphetamine
Systematic name: (RS)-1-(Benzo[d][1,3]dioxol-5-yl)-N-methylpropan-2-amine
Psychoactive class: Stimulant / Entactogen
Chemical class: Amphetamine

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3,4-Methylenedioxymethamphetamine (also known as Ecstasy, XTC, MDMA, MD, Molly, and Mandy, among others) is a widely-used synthetic entactogenic substance of the amphetamine and phenethylamine chemical classes. It produces prototypical entactogenic effects such as anxiety relief, disinhibition, enhanced feelings of empathy, affection, and sociability, muscle relaxation, stimulation, and euphoria when administered

*Chemistry
MDMA, or 3,4-methylenedioxy-N-methylamphetamine, is a synthetic molecule of the substituted amphetamine class. Molecules of the amphetamine class all contain a phenethylamine core comprised of a phenyl ring bound to an amino (NH2) group through an ethyl chain, with an additional methyl substitution at Rα. In addition to this, MDMA contains a methyl substitution on RN, a feature it shares with methamphetamine. Critically, the MDMA molecule also contains substitutions at R3 and R4 of the phenyl ring with oxygen groups -- these oxygen groups are incorporated into a methylenedioxy ring through a methylene bridge. MDMA shares this methylenedioxy ring with other entactogens and stimulants like MDA, MDEA and MDA

*Pharmacology
MDMA is believed to act primarily as a presynaptic releasing agent of the three principal monoamine neurotransmitters serotonin, norepinephrine, and dopamine, which arises from its activity at trace amine-associated receptor 1 (TAAR1) and vesicular monoamine transporter 2 (VMAT2).

MDMA is a monoamine transporter substrate (i.e. a substrate for the transporters for dopamine (DAT), norepinephrine (NET), and serotonin (SERT), enabling it to enter monoaminergic neurons via these neuronal membrane transport proteins. By acting as a monoamine transporter substrate, MDMA produces competitive reuptake inhibition at the neuronal membrane transporters, competing for endogenous monoamines for reuptake.

MDMA inhibits both vesicular monoamine transporters (VMATs), the second of which (VMAT2) is highly expressed within monoamine neurons vesicular membranes. Once inside a monoamine neuron, MDMA acts as a VMAT2 inhibitor and a TAAR1 agonist. The inhibition of VMAT2 by MDMA results in increased concentrations of the aforementioned monoamine neurotransmitters in the cytosol of the neuron.Activation of TAAR1 by MDMA triggers protein kinase signaling events which then phosphorylates the associated monoamine transporters of the neuron.

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Subsequently, these phosphorylated monoamine transporters either reverse transport direction – i.e. move neurotransmitters from inside the cell to the synaptic cleft – or withdraw into the neuron, respectively producing the inflow of neurotransmitters and noncompetitive reuptake inhibition at the neuronal membrane transporters.MDMA has ten times more affinity for uptake at serotonin transporters compared to dopamine and norepinephrine transporters and consequently has mainly serotonergic effects.

To summarize, 1) MDMA first enters monoamine neurons by acting as a monoamine transporter substrate 2) MDMA activity at VMAT2 moves neurotransmitters out from synaptic vesicles and into the cell body and 3) MDMA activity at TAAR1 moves neurotransmitters out of the interior of the cell and into the synaptic cleft, where extra-endogenous concentrations can accumulate.

MDMA also has weak agonist activity at postsynaptic serotonin receptors 5-HT1 and 5-HT2 receptors, and its more efficacious metabolite MDA likely augments this action. Cortisol, prolactin, and oxytocin quantities in serum are increased by MDMA.

A placebo-controlled study in 15 human volunteers found 100 mg MDMA increased blood levels of oxytocin, and the amount of oxytocin increase was correlated with the subjective prosocial effects of MDMA.(S)-MDMA is more effective in eliciting 5-HT, NE, and DA release, while (D)-MDMA is overall less effective, and more selective for 5-HT and NE release (displaying only a very faint efficacy on DA release).

Additionally, MDMA is a ligand at both sigma receptor subtypes, though its efficacies at these receptors and the role that they play have yet to be elucidated.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses

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*Physical effects
Stimulation & Sedation - Regarding its effects on the user's physical energy levels, MDMA is commonly regarded as being stimulating and energetic. This encourages activities such as running, climbing and dancing in a way that makes MDMA a popular choice for musical events such as festivals and raves. The distinct style of stimulation which MDMA presents can be described as forced. This means that at higher doses, it becomes difficult or impossible to keep still as jaw clenching, involuntarily body shakes and vibrations become present, resulting in an unsteadiness of the hands and a general lack of motor control. This can also paradoxically be accompanied by persistent or wave-like feelings of deep sedation and relaxation, typically at moderate to strong doses.
Perception of bodily heaviness - This component typically accompanies any feelings of sedation that this compound can produce.
Perception of bodily lightness - This component typically accompanies any feelings of stimulation that this compound can produce.
Spontaneous physical sensations - The "body high" of MDMA can be characterized as a moderate to extreme euphoric tingling sensation that encompasses the entire body. It is capable of becoming overwhelmingly pleasurable at higher doses. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
Physical euphoria - This component is reliably produced when MDMA is used responsibly (i.e. reasonable dosing and spacing between experiences) and can lead to profound feelings of social and physical disinhibition.
-Tactile enhancement
-Bodily control enhancement
-Stamina enhancement
-Abnormal heartbeat
-Increased blood pressure
-Increased heart rate
-Temperature regulation suppression
-Increased bodily temperature - As MDMA is a serotonin releasing agent, a rise in core body temperature tends to be a significant and consistent part of the experience. Caution must be taken as too high of a dose in a dangerously hot environment can result in serotonin toxicity, which can be fatal if left untreated.
Muscle contractions
-Increased perspiration
Dehydration - Feelings of dry mouth and dehydration are a universal experience with MDMA. While it is important to avoid becoming dehydrated (especially when out dancing in a hot environment) there have been some users suffering from water intoxication through over-drinking, so it is advised that users sip at the water and never over-drink.

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      Buy MDMA  Ecstasy Online

      Buy MDMA Ecstasy Online

      Common names: MDMA, Molly, Mandy, MD, Ecstasy, E, X, XTC, Rolls
      Substitutive name: 3,4-Methylenedioxy-N-methylamphetamine
      Systematic name: (RS)-1-(Benzo[d][1,3]dioxol-5-yl)-N-methylpropan-2-amine
      Psychoactive class: Stimulant / Entactogen
      Chemical class: Amphetamine

      Customers also showed
      interest in the products

      Write your review